This supplemental funding builds on the work from the 2020 Fanconi Cancer Foundation grant awarded to Dr. Grompe, titled Chemoprevention of Cancer in Fanconi Anemia, and additional research supported by the Stand Up To Cancer head and neck cancer team in 2022. Chemoprevention studies are crucial because people with FA have an extremely high risk of developing squamous cell carcinoma (SCC), and standard cancer treatments are often too toxic for them. This project uses advanced animal models to identify compounds that may delay or prevent cancer from developing. It addresses a critical need in FA care by identifying chemopreventive agents that are both safe and effective for this vulnerable population. These findings will help lay the groundwork for future clinical trials, aiming to improve cancer prevention and treatment outcomes for people with FA.