When I was 20 weeks pregnant, my doctor recommended an amniocentesis so we could find out what was causing concerns during my pregnancy. They took amniotic fluid for testing, and that's when my husband and I learned our daughter had a rare genetic disorder called Fanconi anemia (FA). We found out that we were both carriers, something we had never known.
Supported Research
Cancer Prevention in Fanconi Anemia through Alleviating Formaldehyde Genotoxicity
Amount Funded: $488,000
In collaboration with the American Association for Cancer Research, a global leader in cancer research, we’ve presented Dr. Wang with the 2024 Fanconi Cancer Foundation-AACR NextGen Grant for Transformative Cancer Research. Through this groundbreaking work, Dr. Wang seeks to prevent cancer in patients with Fanconi anemia (FA) by targeting specific nutritional and metabolic pathways.
The accumulation of DNA damage and genetic mutations ultimately causes cancer. This process is greatly accelerated in children and young adults with FA. A recent advancement in the field is the discovery that our bodies produce high quantities of reactive chemicals called aldehydes, which cause DNA damage in FA patients. In this project, Dr. Wang will leverage mouse models and FA patient samples to study the nutritional and metabolic pathways that regulate aldehyde production, with the aim of targeting these pathways as novel cancer prevention strategies for FA patients.
Researchers: Meng Wang, MD, PHD
Cancer Prevention in Fanconi Anemia through Alleviating Formaldehyde Genotoxicity
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