Head and neck cancer is a major issue for the FA population. There is no suitable preclinical model to study potential strategies for preventing or delaying squamous cell carcinoma in FA. Using a cancer-prone mouse model developed by a lab in the United Kingdom, researchers will test small molecules that could prevent or delay tumors in these mice. Results will then be used to inform and guide prevention trials in humans. This project is a continuation of the FARF funded Squamous Cell Carcinoma Chemoprevention Phase 1.