Using Fanconi anemia and other genetic disease as a backdrop, Dr. Smogorzewska’s research aims to elucidate pathways that prevent stem cell dysfunction, and cancer development, with a focus on those that repair DNA. Throughout its lifetime, a cell’s DNA is under constant metabolic and environmental assault that can lead to damage. If left unchecked, the resulting genome instability can initiate cancer and a variety of other human disorders. Using Fanconi anemia and other genetic diseases as a backdrop, Smogorzewska’s research aims to elucidate the pathways that protect organ function and prevent cancer, with a focus on those that replicate and repair DNA.