People with Fanconi anemia have an extremely high risk of developing squamous cell cancers of the oral cavity, vulva, anal area, and esophagus. The risk of these cancers starts around teen years and increases throughout life with the highest risk for oral cavity cancers in ages 20s to 30s. Oral cavity cancers arise in areas of changes visible as white or red spots. We plan to screen teens and adults with FA for cancers at regular intervals and study the visible spots in mouth scientifically to identify early changes before progression to cancer. This will help in designing treatments to prevent the development or progression to cancer. People with concerning changes or cancer will be discussed at the tumor board in coordination with FARF and referred for treatment at NIH or elsewhere. Regular screenings and early treatment will offer better chances of cure, will have fewer side effects and result in better quality of life.