Fanconi anemia (FA) patients are at exceptionally high risk of developing epithelial cancers. We aim to identify features of these cancers that provide new insight into their origins, and better ways to treat these cancers in the context of FA patients. As part of this Resource we will develop and characterize FA-deficient and control cancer cell lines to use to test new cancer therapies for FA patients. All data will be freely available, and cell resources available via public cell repositories to enable FA translational research.