Service Grant Archives - Fanconi Cancer Foundation https://fanconi.org/researches-category/service-grant/ Pioneering Research for a Brighter Tomorrow. Tue, 09 Apr 2024 09:08:41 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 https://fanconi.org/wp-content/uploads/2024/04/cropped-fanconi-favicon-32x32.png Service Grant Archives - Fanconi Cancer Foundation https://fanconi.org/researches-category/service-grant/ 32 32 Reducing the burden of squamous cell carcinoma in Fanconi anemia (2020) https://fanconi.org/supported-researches/reducing-the-burden-of-squamous-cell-carcinoma-in-fanconi-anemia-2020/ Wed, 20 Mar 2024 09:12:03 +0000 https://wpbox7.net/ce/dc7ad561/?post_type=app_research&p=2815 As individuals with FA reach adulthood, they have an increased risk of developing cancer, especially head and neck and anogenital squamous cell carcinoma. Cancer treatment options for individuals with FA are limited due to the DNA repair defects associated with the disease. Therefore, there is an urgent need to develop early surveillance and screening modalities […]

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]]> As individuals with FA reach adulthood, they have an increased risk of developing cancer, especially head and neck and anogenital squamous cell carcinoma. Cancer treatment options for individuals with FA are limited due to the DNA repair defects associated with the disease. Therefore, there is an urgent need to develop early surveillance and screening modalities to reduce the burden of advanced disease.

This research project will focus on the four following aims:

1) Non-invasive oral brush biopsy technology, with combined cytologic evaluation, will be implemented in the wider FA community as an early detection screening tool. This will be accomplished by instituting a worldwide training program for medical professionals who will perform brush biopsy screening for people with FA. Medical professionals will include regional local physicians and pathologists.
2) Clinical patient data acquired in a previous brush biopsy clinical trial for patients with FA will be incorporated into a digital platform and analyzed to identify potential cancer-promoting risk factors in the FA population.
3) Educational programs focused on early surveillance will be developed for the FA community to empower individuals with FA to manage their own care in adulthood.
4) Collaborative molecular research projects will focus on the analysis of clinical biological materials collected from the study to develop an understanding of the natural history of squamous cell cancers in individuals with FA.

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]]> Reducing the burden of squamous cell carcinoma in Fanconi anemia – 2018 https://fanconi.org/supported-researches/reducing-the-burden-of-squamous-cell-carcinoma-in-fanconi-anemia-2018/ Wed, 20 Mar 2024 08:53:27 +0000 https://wpbox7.net/ce/dc7ad561/?post_type=app_research&p=2798 Eighty percent of FA patients survive beyond age 20, carry a high risk for squamous cell carcinoma (SCC) of the oropharyngeal and anogenital regions connected with high morbidity and mortality. In addition to intrinsic genetic instability, HSCT and a number of other factors contribute to the pathogenesis of SCC. It is unclear whether external risk […]

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]]> Eighty percent of FA patients survive beyond age 20, carry a high risk for squamous cell carcinoma (SCC) of the oropharyngeal and anogenital regions connected with high morbidity and mortality. In addition to intrinsic genetic instability, HSCT and a number of other factors contribute to the pathogenesis of SCC. It is unclear whether external risk factors for FA SCC are similar to or distinct from risk factors for the general population. The aggressive nature of these tumors mandates early surgical intervention and radiotherapy. In a pilot study of 466 patients, we evaluated the feasibility of replacing traditional invasive biopsy by non-invasive brush biopsy, followed by conventional cytology and/or DNA cytometry. Based on the experience and results of our pilot study, we propose a longitudinal screen of an international FA cohort for the early detection and follow up of head and neck cancer employing soft brush biopsy combined with cytology, DNA cytometry and LOH analysis. Included in these studies will be a questionnaire which correlates disease progression with exposure to environmental risk factors such as oral hygiene, alcohol and tobacco exposure. Cancer tissue from those diagnosed in the screen will be provided for basic and translational research in FA. Ultimate goal of the proposed study is improvement of early detection, timely diagnosis, individualized treatment, and understanding of pathogenesis and prognosis of SCC arising in the context of FA.

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]]> Reducing the burden of squamous cell carcinoma in Fanconi anemia – 2016 https://fanconi.org/supported-researches/reducing-the-burden-of-squamous-cell-carcinoma-in-fanconi-anemia-2016/ Wed, 20 Mar 2024 08:20:23 +0000 https://wpbox7.net/ce/dc7ad561/?post_type=app_research&p=2776 Eighty percent of FA patients survive beyond age 20, carry a high risk for squamous cell carcinoma (SCC) of the oropharyngeal and anogenital regions connected with high morbidity and mortality. In addition to intrinsic genetic instability, HSCT and a number of other factors contribute to the pathogenesis of SCC. It is unclear whether external risk […]

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]]> Eighty percent of FA patients survive beyond age 20, carry a high risk for squamous cell carcinoma (SCC) of the oropharyngeal and anogenital regions connected with high morbidity and mortality. In addition to intrinsic genetic instability, HSCT and a number of other factors contribute to the pathogenesis of SCC. It is unclear whether external risk factors for FA SCC are similar to or distinct from risk factors for the general population. The aggressive nature of these tumors mandates early surgical intervention and radiotherapy. In a pilot study of 466 patients, we evaluated the feasibility of replacing traditional invasive biopsy by non-invasive brush biopsy, followed by conventional cytology and/or DNA cytometry. Based on the experience and results of our pilot study, we propose a longitudinal screen of an international FA cohort for the early detection and follow up of head and neck cancer employing soft brush biopsy combined with cytology, DNA cytometry and LOH analysis. Included in these studies will be a questionnaire which correlates disease progression with exposure to environmental risk factors such as oral hygiene, alcohol and tobacco exposure. Cancer tissue from those diagnosed in the screen will be provided for basic and translational research in FA. Ultimate goal of the proposed study is improvement of early detection, timely diagnosis, individualized treatment, and understanding of pathogenesis and prognosis of SCC arising in the context of FA.

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]]> Reducing the burden of squamous cell carcinoma in Fanconi anemia – 2013 https://fanconi.org/supported-researches/reducing-the-burden-of-squamous-cell-carcinoma-in-fanconi-anemia-2013/ Wed, 20 Mar 2024 07:51:42 +0000 https://wpbox7.net/ce/dc7ad561/?post_type=app_research&p=2747 Today 80% of FA patients survive beyond age 20, carrying a high risk for SCC of the oropharyngeal and anogenital regions connected with high morbidity and mortality. In addition to intrinsic genetic instability, HSCT and a number of other factors contribute to the pathogenesis of SCC. It is unclear whether external risk factors for FA […]

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]]> Today 80% of FA patients survive beyond age 20, carrying a high risk for SCC of the oropharyngeal and anogenital regions connected with high morbidity and mortality. In addition to intrinsic genetic instability, HSCT and a number of other factors contribute to the pathogenesis of SCC. It is unclear whether external risk factors for FA SCC are similar to or distinct from risk factors for the general population. The aggressive nature of these tumors mandates early surgical intervention and radiotherapy. In a pilot study of 466 patients, Dr. Velleuer and Mr. Dietrich evaluated the feasibility of replacing traditional invasive biopsy by non-invasive brush biopsy, followed by conventional cytology and/or DNA cytometry. Based on the experience and results of our pilot study, they propose a longitudinal screen of an international FA cohort for the early detection and follow up of head and neck cancer employing soft brush biopsy combined with cytology, DNA cytometry and LOH analysis. Included in these studies will be a questionnaire which correlates disease progression with exposure to environmental risk factors such as oral hygiene, alcohol and tobacco exposure. Cancer tissue from those diagnosed in the screen will be provided for basic and translational research in FA. The ultimate goal of the proposed study is improvement of early detection, timely diagnosis, individualized treatment, and understanding of pathogenesis and prognosis of SCC arising in the context of FA.

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