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Identifying the nature of the endogenous aldehydes-induced DNA damage that Fanconi anemia DNA repair pathways counteract

2015 | Research Grant | Rui Yu

All living cells form formaldehyde and acetaldehyde through normal metabolism (also from food and alcohol consumption). However, these aldehydes also induce severe DNA damage, which must be tolerated or repaired to prevent diseases. Currently, ~1 billion people in the world have difficulty in detoxi…

The effects of loss of Fanconi gene function on the behavior and therapeutic responses of head and neck cancers

2015 | Research Grant | Ian Mackenzie

In an attempt to explain the high frequency of head and neck cancers in FA patients we have examined differences in the behaviour and signaling pathways of oral epithelial cells (cells that line the oral cavity) lacking Fanconi gene function. Experimental reduction of expression of FA-__A and FA-__C…

Reducing the burden of squamous cell carcinoma in Fanconi anemia - 2013

2013 | Service Grant | Ralf Dietrich, Eunike Velleuer

Today 80% of FA patients survive beyond age 20, carrying a high risk for SCC of the oropharyngeal and anogenital regions connected with high morbidity and mortality. In addition to intrinsic genetic instability, HSCT and a number of other factors contribute to the pathogenesis of SCC. It is unclear …